CIRCA5000 | Pharma Breakthrough
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The Challenge

We all deserve long and healthy lives and innovation in pharmaceuticals is making that a reality. Whether it’s through developing novel treatments for cancers or combatting rare immune diseases, Pharma Breakthrough means better health for all.

This Fund Supports

Our Pharma Breakthrough fund brings together companies undertaking vital research into treating rare diseases, providing medical breakthroughs in areas where there was previously no satisfactory treatment available.

Cancer Treatments
Cancer Treatments
Cures for Neurological Diseases
Cures for Neurological Diseases
Diabetes Research
Diabetes Research
Orphan Drugs Development
Orphan Drugs Development

There are an estimated 6,000-8,000 rare disease affecting 400m people globally. Only 10% of these disease are currently treatable.

Company Spotlight

Here are some of the companies in the fund operating on the cutting edge of medicine and pharmaceuticals to combat rare diseases

Neuro DiseasesEisai

With 15 research centres and nine production sites, Eisai are one of the leaders in cancer and nervous system disease therapies. Through a partnership with the WHO they strive to make sure that those patients who can't pay don't pay.

250m patients provided with free treatment for lymphatic filariasis
Rheumatic DiseasesHorizon Therapeutics

Founded in 2008 by autoimmune and rare disease sufferer Timothy Walbert, Horizon Therapeutics is committed to improving the lives of patients with rare diseases that affect the joints, tendons, ligaments, bones, and muscles.

10 medicines currently on the market
DiabetesVertex

Founded in 1989, Cambridge, Massachusetts-based Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases including diabetes and cystic fibrosis.

20 live drug discovery programmes
Neuro DiseasesEisai

With 15 research centres and nine production sites, Eisai are one of the leaders in cancer and nervous system disease therapies. Through a partnership with the WHO they strive to make sure that those patients who can't pay don't pay.

250m patients provided with free treatment for lymphatic filariasis
Rheumatic DiseasesHorizon Therapeutics

Founded in 2008 by autoimmune and rare disease sufferer Timothy Walbert, Horizon Therapeutics is committed to improving the lives of patients with rare diseases that affect the joints, tendons, ligaments, bones, and muscles.

10 medicines currently on the market
DiabetesVertex

Founded in 1989, Cambridge, Massachusetts-based Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases including diabetes and cystic fibrosis.

20 live drug discovery programmes
Neuro DiseasesEisai

With 15 research centres and nine production sites, Eisai are one of the leaders in cancer and nervous system disease therapies. Through a partnership with the WHO they strive to make sure that those patients who can't pay don't pay.

250m patients provided with free treatment for lymphatic filariasis
Rheumatic DiseasesHorizon Therapeutics

Founded in 2008 by autoimmune and rare disease sufferer Timothy Walbert, Horizon Therapeutics is committed to improving the lives of patients with rare diseases that affect the joints, tendons, ligaments, bones, and muscles.

10 medicines currently on the market
DiabetesVertex

Founded in 1989, Cambridge, Massachusetts-based Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases including diabetes and cystic fibrosis.

20 live drug discovery programmes

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Holdings data taken from fundcentres.lgim.com, rizeetf.com and ishares.com in July 2022. Both the holdings and the number of holdings in any fund can change from time to time.

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